abstract::Objective: The outcomes of alternative donor hematopoietic stem cell transplantation (HSCT) with unmanipulated grafts for Inherited bone marrow failure syndromes (IBMFS) are discouraging. Our study is to demonstrate that IBMFS with disease-specific characteristics requires a tailored conditioning regimens to enhance e...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1876393
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:Hodgkin lymphoma (HL) involving the Waldeyer's ring (WR) and other extranodal head and neck sites are rare. We report our experience and PubMed literature review. METHODS:Retrospective single institution cohort study using lymphoma data base and PubMed literature search using twenty-six various search ter...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1865667
更新日期:2021-12-01 00:00:00
abstract::For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer's disease and improve the pharmacokinetic properties of existing drugs. In the present study, we used three docking-based virtual screening approaches to scre...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1876685
更新日期:2021-12-01 00:00:00
abstract::In discovery of HDAC inhibitors (HDACIs) with improved anticancer potency, structural modification was performed on the previous derived indole-3-butyric acid derivative. Among all the synthesised compounds, molecule I13 exhibited high HDAC inhibitory and antiproliferative potencies in the in vitro investigations. The...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1870457
更新日期:2021-12-01 00:00:00
abstract::Nine compounds (MO1-MO9) containing the morpholine moiety were assessed for their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). Most of the compounds potently inhibited MAO-B; MO1 most potently inhibited with an IC50 value of 0.030 µM, followed by MO7 (0.25 µM). MO5 most pote...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1842390
更新日期:2021-12-01 00:00:00
abstract::Hyperthermic intraperitoneal chemotherapy (HIPEC) is administered to treat residual microscopic disease after debulking cytoreductive surgery. During HIPEC, a limited number of catheters are used to administer and drain fluid containing chemotherapy (41-43 °C), yielding heterogeneities in the peritoneum. Large heterog...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1862364
更新日期:2021-12-01 00:00:00
abstract::Five series of novel carbazole derivatives containing an aminoguanidine, dihydrotriazine, thiosemicarbazide, semicarbazide or isonicotinic moiety were designed, synthesised and evaluated for their antimicrobial activities. Most of the compounds exhibited potent inhibitory activities towards different bacterial strains...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1850713
更新日期:2021-12-01 00:00:00
abstract::Work undertaken using the embryonic carcinoma 2102Ep line, highlighted the requirement for robust, well-characterized and standardized protocols. A systematic approach utilizing 'quick hit' experiments demonstrated variability introduced into culture systems resulting from slight changes to culture conditions (route A...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1870074
更新日期:2021-12-01 00:00:00
abstract::Bordetella (B.) bronchiseptica and Streptococcus (S.) suis are major pathogens in pigs, which are frequently isolated from co-infections in the respiratory tract and contribute to the porcine respiratory disease complex (PRDC). Despite the high impact of co-infections on respiratory diseases of swine (and other hosts)...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1858604
更新日期:2021-12-01 00:00:00
abstract::Collagen type X alpha 1 (COL10A1) is a member of the collagen family and the main matrix component. However, COL10A1 expression and prognosis relationship remains unclear in gastric cancer (GC). Through the analysis of database of Oncomine, the Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus (GEO), i...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1864912
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:Ras-related dexamethasone-induced 1 (RASD1) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, RASD1, as a potential target fo...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1860359
更新日期:2021-12-01 00:00:00
abstract::Candida glabrata is an opportunistic human fungal pathogen and is frequently present in the human microbiome. It has a high relative resistance to environmental stresses and several antifungal drugs. An important component involved in microbial stress tolerance is trehalose. In this work, we characterized the three C....
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1868825
更新日期:2021-12-01 00:00:00
abstract::The main aim of the work is to study the regulation of gene expression in the interaction between rice and Magnaporthe oryzae by gene chip technology. In this study, we mainly focused on changes of gene expression at 24, 48, and 72 hours post-inoculation (hpi), through which we could conduct a more comprehensive analy...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1860479
更新日期:2021-12-01 00:00:00
abstract::Staphylococcus aureus (S. aureus) is a clinical pathogen of great significance causing metastatic or complicated infections. ST5 clonotype isolates have dominated S. aureus infections for more than 10 years in Shanghai, China, and the proportion of methicillin-susceptible S. aureus (MSSA) has remarkably increased in t...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1868950
更新日期:2021-12-01 00:00:00
abstract::Strategies to control spread of highly pathogenic avian influenza (HPAI) viruses by wild birds appear limited, hence timely characterization of novel viruses is important to mitigate the risk for the poultry sector and human health. In this study we characterize three recent H5-clade 2.3.4.4 viruses, the H5N8-2014 gro...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1868274
更新日期:2021-12-01 00:00:00
abstract::Acinetobacter baumannii has become a major healthcare threat that causes nosocomial infections, especially in critically ill patients. The spread of carbapenem-resistant A. baumannii (CRAB) strains has long been a clinical concern. It is important to study the epidemiology and virulence characteristics of different CR...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1856560
更新日期:2021-12-01 00:00:00
abstract::The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A small-molecule inhib...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1843452
更新日期:2021-12-01 00:00:00
abstract::In the current study, virtual screening of a small library of 1302 pyrrolizines bearing urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated for their cytotoxicity against three cancer (MCF-7, A2780, and HT29) and one normal (MRC-5) cell lines. The results of the MTT assay revealed...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1837124
更新日期:2021-12-01 00:00:00
abstract::In this study, we fabricate physically dual-crosslinked cellulose-based hydrogels by varying coordination bonding effects with the addition of either divalent or trivalent metal cations. The first crosslinked network is created by metal-carboxylate coordination bonds between the cellulose nanofibrils that have abundan...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118515
更新日期:2021-11-15 00:00:00
abstract::An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer po...
journal_title:Carbohydrate polymerspub_type: 杂志文章,评审
doi:10.1016/j.carbpol.2021.118491
更新日期:2021-11-15 00:00:00
abstract::Carbohydrate analysis has always been a challenging task due to the occurrence of high polarity and multiple isomers. Aldoses are commonly analyzed by gas liquid chromatography (GLC) following aldononitrile acetate derivatization (AND). However, the GLC technique cannot be applied for the simultaneous determination of...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118478
更新日期:2021-11-15 00:00:00
abstract::The properties of chiral nematic and iridescent cellulose nanocrystal films with different monovalent cations (CNC-X) obtained through evaporation-induced self-assembly (EISA) can be modified by a variety of external stimuli. Here, we study the transformations of their optical and structural properties when the films ...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118468
更新日期:2021-11-15 00:00:00
abstract::In 2020, Brazil was the leading country in COVID-19 cases in Latin America, and capital cities were the most severely affected by the outbreak. Climates vary in Brazil due to the territorial extension of the country, its relief, geography, and other factors. Since the most common COVID-19 symptoms are related to the r...
journal_title:Expert systems with applicationspub_type: 杂志文章
doi:10.1016/j.eswa.2021.115190
更新日期:2021-11-15 00:00:00
abstract::The objective of this study was to assess the ability of utilizing attenuated total reflection mid-infrared (ATR-MIR) spectroscopy in combination with machine learning techniques to classify the presence of different types of microplastics in artificially adulterated fish and seafood samples. Different polymers namely...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119985
更新日期:2021-11-05 00:00:00
abstract::Herein, we propose an eco-friendly synthesis of carbon dots (CDs) and ingeniously design a rapid and label-free "turn-off" sensing platform for ultrasensitive recognition of Fe3+ in vitro and in vivo. CDs with extraordinary advantages involving exceptional stability, ultra-low toxicity as well as admirable biocompatib...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119964
更新日期:2021-11-05 00:00:00
abstract::Thermal papers are replacing the conventional form of printing and are being extensively used across the globe. This study encompasses a non-destructive approach to examine thermal papers by using ATR-FTIR spectroscopy and Video Spectral Comparator (VSC), where the former technique helps in characterizing and discrimi...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119982
更新日期:2021-11-05 00:00:00
abstract::GdNbTiO6: Sm3+ phosphors with various Sm3+ concentrations were prepared via a high temperature solid-state reaction method. The crystal structure of the samples was characterized by means of X-ray diffraction (XRD) and the as-prepared samples were confirmed to be orthorhombic phase GdNbTiO6. Photoluminescence properti...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119951
更新日期:2021-11-05 00:00:00
abstract::Erlotinib hydrochloride (Erlo) is used in the treatment of non-small cell lung cancer, pancreatic cancer and other types of cancer. Interaction of small molecules with bio-macromolecules can lead to changes in the structure and function of them which is one of the possible side effects of the drugs. In this study, the...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119940
更新日期:2021-11-05 00:00:00
abstract::A new fluorescent probe (MBT) for the detection of 4-methylbenzenethiol (p-MePhSH) was developed by using 4-(benzo[d]thiazol-2-yl)-3-methoxyphenol as the fluorophore and 2,4-dinitrophenyl ether as the sensing moiety. Probe MBT displayed good selectivity toward p-MePhSH in DMSO/PBS buffer (5/5, v/v) solution and anti-i...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119947
更新日期:2021-11-05 00:00:00
abstract::Dimethyl sulfoxide (DMSO) is routinely applied as an excellent, water-miscible solvent and chemical reagent. Some of the most important data concerning its liquid structure were obtained using infrared (IR) spectroscopy. However, the actual extent of intermolecular correlations that connect the isolated monomer spectr...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119869
更新日期:2021-11-05 00:00:00
abstract::Absorption and relaxation dynamics of electronic states of free-base, Co(II), Cu(II) and Zn(II) porphyrins bearing a β-(2,2-difluoro-1,3,2-dioxaborinin-5-yl) group were investigated in dimethyl sulfoxide by using distinct time-resolved spectroscopic techniques. Furthermore, excited state absorption cross-section spect...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119911
更新日期:2021-11-05 00:00:00
abstract::Natural agents have been used to restart the process of differentiation that is inhibited during leukemic transformation of hematopoietic stem or progenitor cells. Autophagy is a housekeeping pathway that maintains cell homeostasis against stress by recycling macromolecules and organelles and plays an important role i...
journal_title:Molecular medicine reportspub_type: 杂志文章
doi:10.3892/mmr.2021.12386
更新日期:2021-11-01 00:00:00
abstract::Life-threatening COVID-19 pneumonia follows an exaggerated immune response to SARS-CoV-2. pGSN levels fall after SARS-CoV-2 infection. Rhu-pGSN improves outcomes in models of inflammation. In an intubated patient with critical COVID-19 pneumonia and progressive hypoxemia despite standard care, improvement became evide...
journal_title:Clinical infection in practicepub_type:
doi:10.1016/j.clinpr.2021.100088
更新日期:2021-11-01 00:00:00
abstract::In this study, a new PLS-DA modelling approach for multi-class discriminant analysis, called Common-Subset-of-Independent-Variables Partial-Least-Squares Discriminant Analysis is proposed and evaluated. Because in this method Partial-Least-Squares models for one component are used, it is denoted as CSIV-PLS1-DA. In th...
journal_title:Talantapub_type: 杂志文章
doi:10.1016/j.talanta.2021.122595
更新日期:2021-11-01 00:00:00
abstract::We conducted a field experiment to study the effect of framing future moments in time as new beginnings (or "fresh starts"). University employees (N=6,082) received mailings with an opportunity to choose between increasing their contributions to a savings plan immediately or at a specified future time point. Framing t...
journal_title:Organizational behavior and human decision processespub_type: 杂志文章
doi:10.1016/j.obhdp.2021.06.005
更新日期:2021-11-01 00:00:00
abstract::In recent years, chitosan-based biomaterials have been continually and extensively researched by using layer-by-layer (LBL) assembly, due to their potentials in biomedicine. Various chitosan-based LBL materials have been newly developed and applied in different areas along with the development of technologies. This wo...
journal_title:Carbohydrate polymerspub_type: 杂志文章,评审
doi:10.1016/j.carbpol.2021.118427
更新日期:2021-11-01 00:00:00
abstract::Herein, a novel paper-based chemiluminescence (CL) assay is reported using a smartphone readout for on-site and reliable analytical applications. The CL system was based on the high-performance improving effect of cobalt-imidazole metal-organic framework (CoMOF) on luminol-hydrogen peroxide (H2O2) CL emission. The CoM...
journal_title:Talantapub_type: 杂志文章
doi:10.1016/j.talanta.2021.122648
更新日期:2021-11-01 00:00:00
abstract::This present work evaluated the effect of heat fluidization, microwave roasting and baking treatment of highland barley (HB) on the molecular, structural, thermal and antioxidant characteristics of β-glucan. Fluorescence microscopy results showed that heat fluidization exhibited the greatest disruption effect on endos...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118416
更新日期:2021-11-01 00:00:00
abstract::The Cytochrome P450 CYP1A2 is a central enzyme in the metabolism of drugs and xenobiotics. The overall activity of this enzyme is influenced by a complex array of biochemical, dietary, and genetic factors. One of the simplest ways to probe the overall output of CYP1A2 is to measure the ratio between the concentration ...
journal_title:Talantapub_type: 杂志文章
doi:10.1016/j.talanta.2021.122658
更新日期:2021-11-01 00:00:00
abstract::A dual-readout immunoassay based on QDs-FM@ALP-SA and click chemistry was developed for quick and sensitive detection of norfloxacin (NOR), which is an important fluoroquinolone antibiotic. In the system, the NOR-biotin conjugate (NOR-Biotin) was synthesized by click chemistry for signal transformation, and alkaline p...
journal_title:Talantapub_type: 杂志文章
doi:10.1016/j.talanta.2021.122703
更新日期:2021-11-01 00:00:00